Minimally invasive microneedles for ocular drug delivery
نویسندگان
چکیده
منابع مشابه
Microneedles for Ocular Drug Delivery
Statement of Purpose: Targeted drug delivery into the eye is a challenging task because of a variety of barriers that prevent safe and effective delivery. Topical application to the eye is hindered by low residence time resulting in poor diffusion of drug into intraocular tissues. Intravitreal injection can deliver drugs to the retina effectively but is invasive and carries risk of infection. I...
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To my dearest parents For their love, trust and supports ACKNOWLEGMENT I would like to thank my advisor, my thesis committee members, my research colleagues, my family and my friends who made this thesis possible. I would like to thank my thesis advisor, Mark Prausnitz for his support during my thesis work. Without his guidance, it would be difficult for me to complete my study. I would like to...
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Many ocular inflammatory and proliferative diseases require long-term pharmacological intervention/treatment. However, delivery of drugs in therapeutic levels to the back of the eye is challenging using conventional topical application, due to the poor efficacy. Systemic injections of drugs pose severe adverse effects. Direct injection into the eye may need surgical intervention. In the recent ...
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Biomolecules, including proteins, peptides, and vaccines, make up a large and potent portion of all new drugs and hold great promise for the future of therapeutics. Although oral delivery of these biotherapeutics would be desirable, there is low bioavailability of biomolecules administered by this route due to enzymatic degradation and poor absorption in the GI tract, as well as first-pass meta...
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The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at therapeutically useful rates. Recently, the use of micron-scale needles in increasing skin permeability has been proposed and shown to dramatically increase transdermal delivery, especially for macromolecules. Using the tools of the microelectronics industry, microneedles have ...
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ژورنال
عنوان ژورنال: Expert Opinion on Drug Delivery
سال: 2016
ISSN: 1742-5247,1744-7593
DOI: 10.1080/17425247.2016.1218460